Upstream Processing (USP)

At Celonic, upstream processing starts the adaptation to serum- and protein-free medium, if necessary. Afterwards, optimal conditions are identified at small scale cultivation (medium, pH, pO2, supplements, cell density). That is done by parallel cultivation in shake flasks. The first upscaling is done until 1.3 L and the second from 1.3 L to 13 liters stirred tank or 20 liters Wave bioreactors followed by a further upscaling to GMP-production. Celonic – your partner in integrative process development.

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